Invasion

Tumor cell invasiveness is a critical challenge in the clinical management of glioma patients. In addition, there is accumulating evidence that current therapeutic modalities, including anti-angiogenic therapy and radiotherapy, can enhance glioma invasiveness. Below is a schematic presentation on how malignant gliomas grow in the human brain as well as an example og our human glioblastoma xenografts growing in the immunodeficient rat brain.

Figure invasjon

We have an active research programme focusing on delineating the mechanisms behind the invasive growth of human GBMs where a specific focus is on the Epidermal Growth Factor Receptor (EGFR) system and downstream cell signaling events involved in invasive  growth.