Principle Investigator Prof. MD. Hrvoje Miletic Office phone: +55 97 2592 Email: email@example.com
The Miletic Research Group works on projects within basic and translational brain tumour research aimed toward both gaining a better understanding of invasive and angiogenic mechanisms of brain tumours and developing experimental therapies. Two major research topics in our lab include:
- Identifying molecular mechanisms of invasion and angiogenesis within human brain tumours
- Translation of a lentiviral suicide gene therapy into the clinic to treat brain tumour patients
To achieve these goals, we use animal models that recapitulate the invasive and angiogenic features of patient tumours.
Using these models, we have recently shown that EGFR promotes invasion of tumour cells into brain tissue and that this process is independent of angiogenesis (Talasila et al., Acta Neuropathologica, 2013). Through the PI, who is senior consultant in neuropathology, the Miletic Research group is connected to other research topics within oncology, neurology, pathology and neuropathology via a number of collaborations. Please visit our Home Page (neuroconcept.org) for more information.